20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8868 | 4BP-TQS | AChR | |
4BP-TQS is an allosteric agonist of α7 nAChRs. | |||
T10573 | BMT-145027 | GluR | |
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM). | |||
T17300 | (-)-(S)-B-973B | AChR | |
(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR. | |||
T3565 | VU0155041 | UV0155041,VU-0155041 | GluR |
VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat). | |||
T11458 | GPR40/FFAR1 modulator 1 | GPR | |
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. | |||
T1760 | TBPB | AChR | |
TBPB is an allosteric M1 mAChR agonist. | |||
T3961 | CYM-5541 | CYM 5541,ML249,CID-17253208 | S1P Receptor , LPL Receptor |
CYM-5541 (ML249) is a selective and allosteric S1P3 receptor agonist. | |||
T6575 | LY2119620 | AChR | |
LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors. | |||
T8403 | Cinacalcet | AMG 073 | CaSR |
Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease . | |||
T12192 | NCGC00229600 | Others , TSH Receptor | |
NCGC00229600 is an allosteric inverse thyrotropin receptor (TSHR) agonist. NCGC00229600 inhibits both TSH and stimulating antibody activation of TSHRs endogenously and can be used in Graves' disease studies. | |||
T2635 | Org 27569 | Cannabinoid Receptor | |
Org 27569, an allosteric modulator of cannabinoid CB1 receptor, can induce a CB1 receptor state that is characterized by decreased inverse agonist affinity and enhanced agonist affinity. | |||
T8642 | 4-CMTB | GPR | |
4-CMTB is a selective agonist of FFA2 and GPR43.It also is a positive allosteric modulator (pEC50=6.38). | |||
T22703 | CYM-5520 | CYM 5520 | S1P Receptor , LPL Receptor |
CYM-5520 is a noncompetitive allosteric agonist of S1P2 | |||
T10814 | Cinacalcet metabolite M4 | Rarechem AL BW 1078 | Calcium Channel |
Cinacalcet metabolite M4 (Rarechem AL BW 1078) is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor. | |||
T8224 | VU0119498 | AChR | |
VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent. | |||
T7165 | Basmisanil | RG1662,RO5186582 | GABA Receptor |
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro... | |||
T22301 | L-838417 D9 | CTP354,CTP354 (C-21191),C-21191 | GABA Receptor |
L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1]. | |||
T12165 | NAChR agonist 1 | DUN71755 | AChR |
nAChR agonist 1 (DUN71755) is a brain-permeable and orally efficacious positive allosteric α7 nicotinic acetylcholine receptor (α7 nAChR)modulator. | |||
T15363 | FzM1.8 | Wnt/beta-catenin | |
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway. | |||
T21935L | AMN082 free base | AMN082 | GluR |
AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist. |